The Division’s basic neuroscience research is primarily conducted within the Brain Research Center at the UBC Campus. Areas of research include a focus on neuroimmunology, neurovirology and neurochemistry.
Dr. Wang’s Laboratory
The long-standing research interest in Dr. Yu Tian Wang’s laboratory has been on understanding the fundamental mechanisms controlling synaptic transmission among neurons in the brain, and the dysfunction of these mechanisms in the pathogenesis of brain disorders such as epilepsy, stroke, and learning deficits. In particular, over the last year, Dr. Wang and colleagues have made significant progresses on elucidating molecular mechanisms underlying the formation of learning and memory (Mol Brain. 4:41, 2011; Neuron 72:682, 2011; J. Physiol. 589:4321, 2011). Through these mechanistic studies, they have developed and tested several interference peptides as novel therapeutics for treatments of developmental abnormalities such as abnormal ocular dominance plasticity (amblyopia) (Sci Rep. 1:203, 2011) and learning and memory disorders (Learn Mem. 18:283, 2011; Neuropharmacol. 62:797, 2012) in various animal models. In addition, in their most recent studies, they have identified a novel glutamate binding site on glycine and on GABA-A chloride channel receptors (Nature Neurosci., 13:1225, 2010), leading to their recent efforts of screening novel ligands which may be developed into therapeutic small molecules for reducing seizure and/or brain injuries following stroke.
The labs of Drs. Steven Pelech, Joel Oger, Lorne Kastrukoff, and Neil Cashman contribute to divisional research in basic neuroscience research.