Dr. Daryl Wile

Parkinson’s disease, information technology, noninvasive disease monitoring, telemedicine, neuroimaging, genetics.

Dr. Wile is a Neurologist with clinical and research activities focusing on Parkinson Disease. Interests include the application of information technology and telemedicine services to unique clinical needs (e.g. remote assessment of movement disorders) and geographical needs (e.g. underserved areas). Research interests also include dysfunction of non-dopamine brain chemical systems in Parkinson Disease. He is Principal Investigator for ParkinSMART, a study of symptom monitoring and activity recording technology in Parkinson Disease, and a site Principal Investigator for a clinical trial of disease-modifying therapy in Progressive Supranuclear Palsy. He is also a Clinical Education Leader for Neurology at the UBC Southern Medical Program in Kelowna.

University of British Columbia, BSc, Psychology

McGill University, MSc, Behavioral Neuroscience

University of Calgary, MD

Member, Postgraduate Medical Education Neurology Residency Training Committee

Member, Interior Health Authority Research Ethics Board

Liu, SY, Wile, DJ, Fu, JF, Valerio, J, Shahinfard, E, McCormick, S, Mabrouk, R, …. The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson’s disease: a cross-sectional PET study. The Lancet Neurology. 2018; 17(4), 309-316

Fu, JF, Klyuzhin, I, Liu, S, Shahinfard, E, Vafai, N, McKenzie, J, Neilson, N, …. Investigation of serotonergic Parkinson’s disease-related covariance pattern using [11C]-DASB/PET. NeuroImage: Clinical. 2018; 19, 652-660

Matarazzo, M, Wile, D, Mackenzie, M, Stoessl, AJ. PET Molecular Imaging in Familial Parkinson’s Disease.. International review of neurobiology. 2018; 142, 177-223

Mackle, T, Wile, D. Arachnoid cysts and adult onset epilepsy. Canadian Medical Association Journal 189 (7), E280-. 2017;, e280

Perez‐Soriano, A, Arena, JE, Dinelle, K, Miao, Q, McKenzie, J, Neilson, N, …. PBB3 imaging in parkinsonian disorders: evidence for binding to tau and other proteins. Movement Disorders. 2017; 32(7), 1016-1024

Wile, DJ, Agarwal, PA, Schulzer, M, Mak, E, Dinelle, K, Shahinfard, E, Vafai, N, …. Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies. The Lancet Neurology. 2017; 16(5), 351-359

Wile, DJ, Sossi, V, Stoessl, AJ. Reply to letter to the editor: Is there anything more to learn from SWEDD?. Movement Disorders. 2016; 31(9), 1426-1428

DJ, SAJ Wile, K, Dinelle, N, Vafai, J, McKenzie, JK, Tsui, P, Schaffer, …, Ding YS. A scan without evidence is not evidence of absence: Scans without evidence of dopaminergic deficit in a symptomatic leucine-rich repeat kinase 2 mutation carrier.. Movement Disorders. 2016; 31(3), 405-409

Wile, DJ, Ranawaya, R, Kiss, ZHT. Smart watch accelerometry for analysis and diagnosis of tremor. Journal of neuroscience methods. 2014; 230, 1-4

Wile, DJ, Warner, J, Murphy, W, Lafontaine, AL, Hanson, A, Furtado, S. Referrals, wait times and diagnoses at an urgent neurology clinic over 10 years. Canadian Journal of Neurological Sciences. 2014; 41(2), 260-264

Wile, DJ, Pringsheim, TM. Behavior therapy for Tourette syndrome: a systematic review and meta-analysis. Current treatment options in neurology. 2013; 15(4), 385-395

Wile, D, Dhaliwal, H, Sarna, JR, Molnar, CP, Scott, JN, Costello, F, Furtado, S, …. Diaschisis as the presenting feature in sporadic Creutzfeldt-Jakob disease. JAMA neurology. 2013; 70(3), 408-409

See also: Google Scholar https://scholar.google.ca/citations?user=k_eyQyoAAAAJ&hl=en

Foundations of Medical Practice II – Clinical Skills

Foundations of Medical Practice III – Clinical Skills

Internal Medicine – Clinical Clerkship – Outpatient / Ambulatory

Foundations of Medical Practice III – Lectures & Labs